Do you mean you get "Extension VLsub does not respond. Do you want to kill it now" / "Extension 'VLsub 0.11.0' does not respond. Do you want to kill it now" ?
If so: http://api.opensubtitles.org/xml-rpc looks down: time-out message after 18 seconds. With some cloudflare info, so that is probably Cloudflare not able to talk to the real server.
I hacked this into my hosts file:
# hack for VLsub while the real api.opensubtitles.org is timing-out
92.240.234.122 api.opensubtitles.org
... now VLsub works again.
EDIT:
The real IP addresses for api.opensubtitles.org are indeed Cloudflare IP addresses:
api.opensubtitles.org has address 104.25.132.104
api.opensubtitles.org has address 104.25.131.104
EDIT 2:
So not a Windows problem, but a server side problem. I wrote a patch for VLsub to at least handles the problem better with a message. See https://trac.videolan.org/vlc/ticket/22695