Don't die before you read my reply. I tried something similar: VLC = ['/Applications/VLC.app/Contents/MacOS/VLC', '-I', 'macosx', '--extraintf=lua', '--lua-intf=rc', '--lua-config="rc={host=\'localhost:4222\'}"', '/Users/me/Desktop/image.jpg'] vlc = subprocess.Popen(VLC) And it always gave...