Assuming that iOS has true USB Audio Class 2.0 support, you could potentially use something like this:
https://sewelldirect.com/Soundbox-Pro-USB-Sound-Card
I've got one on order to test out right now, hence my questions.
There's more than a handful of devices that support multichannel input on iOS, using the camera connector kit. But I can't seem to find similar info for multichannel output.
http://en.ntrack.com/pro-audio-on-ipad.php
EDIT: RME also claim that their device supports iOS:
http://www.rme-audio.de/en/products/fireface_ucx.php
"Playback will use analog outputs 1 and 2, or even more channels if the app supports such operation. The UCX can optionally copy the iPad playback channels 1/2 to outputs 7/8 and SPDIF/ADAT, for easier monitoring. All outputs can be processed independently (volume, EQ, dynamics, FX return)."